The synthesis of 5-[hydl. oxy-2-[(l-methyl-3-phenylpropyl) amino] ethyl]-1H-indole-7- carboxide, 5, a pyrrolo analogue of labetalol, is described. Compound 5 was found to reduce blood pressure in spontaneously hypertensive rats with an EDm of 5 mg/kg PO, without causing any decrease in heart rate. Isolated tissue studies with 5 shows that it is a nonselective 8-adrenoceptor antagonist and that it is a weaker a-adrenoceptor antagonist ...
![1-(1-acetyl-2,3-dihydro-1H-indol-5-yl)-2-[bis(phenylmethyl)amino]ethanone Structure](https://image.chemsrc.com/caspic/303/101544-38-1.png)
![2,3-dihydro-5-[1-hydroxy-2-[bis(phenylmethyl)amino]ethyl]-1H-indole-7-carboxamide Structure](https://image.chemsrc.com/caspic/258/101544-44-9.png)
![1-acetyl-α-[[bis(phenylmethyl)amino]methyl]-2,3-dihydro-1H-indole-5-methanol acetate ester Structure](https://image.chemsrc.com/caspic/410/101544-40-5.png)