Helvetica Chimica Acta

Eine ergiebige Herstellung von 1α, 3β??Dihydroxy?螃?5??steroiden durch Reduktion von 1α, 2α??Epoxy??4, 6??dien??3??onen mit Lithium in Ammoniak

A Fürst, L Labler, W Meier

Index: Fuerst, Andor; Labler, Ludvik; Meier, Werner Helvetica Chimica Acta, 1981 ,  vol. 64,  # 6  p. 1870 - 1892

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Citation Number: 9

Abstract

Summary A number of 1 a, 3~-dihydroxy-A5-steroids of the cholestane,(20S)-20- methylpregnane (23, 24-dinorcholane), pregnane and androstane series were synthesized from common steroidal precursors. A process originally reported by Barton et al., based on 1, 4, 6-trien-3-ones as intermediates, was used for the introduction of the 1 a-hydroxyl function. The last step of this process, consisting of lithium/ammonia reduction of 1 a, 2a- ...