Tetrahedron letters

A versatile asymmetric synthesis of highly enantiomerically enriched 12 (S)-HETE via a combination of enzymatic and chemical processes

YG Suh, KH Min, YS Lee, SY Seo, SH Kim, HJ Park

Index: Suh, Young-Ger; Min, Kyung-Hoon; Lee, Yong-Sil; Seo, Seung-Yong; Kim, Seok-Ho; Park, Hyun-Ju Tetrahedron Letters, 2002 ,  vol. 43,  # 21  p. 3825 - 3828

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Citation Number: 8

Abstract

Arachidonic acid is metabolized through the 12-lipoxygenase (12-LOX) and the cytochrome P-450 pathways to produce 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE, 1a) and 12(R)-hydroxyeicosatetraenoic acid (12(R)-HETE, 1b), respectively. These two endogenous substances have recently been discovered to be implicated in a number of important biological activities such as hypertension, thrombosis, metastasis of tumor cell, angiogenesis, and ...