Abstract A series of substituted phenylethanolaminotetralins were synthesized as pure stereoisomers and their ability to stimulate atypical β-adrenoceptors selectively was evaluated. The compounds in vitro relative potencies were assessed using the atypical β response of inhibition of rat proximal colon motility and the typical β1 (increase in guinea-pig right atrial frequency) and β2 (guinea-pig tracheal relaxation and rat uterus motility ...
