e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis of 5-aryl-2H-tetrazoles, 5-aryl-2H-tetrazole-2-acetic acids, and [(4-phenyl-5-aryl-4H-1, 2, 4-triazol-3-yl) thio] acetic acids as possible superoxide scavengers …
…, DA Wasdahl, AC Wolfson, VI Stenberg
Index: Maxwell, James R.; Wasdahl, Dan A.; Wolfson, Alan C.; Stenberg, Virgil I. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1565 - 1570
A series of B-aryl-W-tetrazoles, 5-aryl-W-tetrazole-2-acetic acids, and [(4-phenyl-5-aryl-4H-1, 2, 4-triazol-3-yl) thio] acetic acids were synthesized and tested in vitro for superoxide scavenging activity, in vivo in the carrageenan-induced rat paw edema assay, and in the reverse passive Arthus reaction. The hydroxy-substituted compounds were effective as in vitro scavengers of superoxide but were not effective as in vivo antiinflammatory agents.
