Synthetic Communications

Aromatic Nucleophilic Substitution: The Reaction of Sodium 2, 2, 2-Trifluoroethoxide with Chlorobenzonitriles in HMPA

JT Gupton, JP Idoux, C Colon…

Index: Gupton, John T.; Idoux, John P.; Colon, Cesar; Rampi, Rick Synthetic Communications, 1982 , vol. 12, # 9 p. 695 - 700

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Citation Number: 9

Abstract

Abstract The preparation1 of fluorinated compounds continues to be of significant interest to organic chemists due to their diverse and important application as polymers, blood substitutes, pharmaceuticals and pesticides. Considerable attention has been directed to the formation of fluoroalkoxy benzenes with the majority of the synthetic routes involving the reaction of an electrophilic haloalkyl fluoride with a nucleophilic phenol derivative1, 2. In a ...