Synthesis and radioprotective activity of germa and silathiazolidines

J Satge, A Cazes, M Bouchaut, M Fatome…

Index: Satge; Cazes; Bouchaut; et al. European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 433 - 436

Full Text: HTML

Citation Number: 26

Abstract

Synthesis of many isologues from the IVb series of thiazolidines has been carried out by replacing the carbon atom in the 2 position by a germanium or a silicon atom. These compounds have generally a higher radioprotective activity with a DRF greater than those of cysteamine and also a higher toxicity in the case of germanium derivatives