Bioorganic & medicinal chemistry

Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles

H Göker, DW Boykin, S Yıldız

Index: Goeker, Hakan; Boykin, David W.; Yildiz, Sulhiye Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1707 - 1714

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Citation Number: 78

Abstract

Series of flavones and methyl-4H-1-benzopyran-4-ones carrying mono or diamidinobenzimidazoles at different positions were synthesized and evaluated for antibacterial and antifungal activities against E. coli, S. aureus, MRSA (methicillin-resistant S. aureus), MRSE (methicillin-resistant S. epidermidis), S. faecalis and C. albicans, C. krusei. The results showed that while all diamidines are inactive, the compounds having ...