The Willgerodt-Kindler reaction in water: High chemoselectivity of benzaldehydes over acetophenones

K Aghapoor, F Mohsenzadeh, G Khanalizadeh…

Index: Aghapoor, Kioumars; Mohsenzadeh, Farshid; Khanalizadeh, Golriz; Darabi, Hossein R. Monatshefte fur Chemie, 2007 , vol. 138, # 1 p. 61 - 65

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Citation Number: 8

Abstract

Summary. Water has been found for the first time as a useful solvent in the Willgerodt- Kindler (WK) reaction for the synthesis of benzothiomorpholides in high yield at 80° C for 3 h. This novel approach confronts the WK protocol with a new situation in which water not only is not regarded as a serious disadvantage but also is applied in this case as a useful solvent in the reaction. The basis of this finding is the presence of a methylene chain in the ...