Improved preparation of the clathrate host compound tri-o-thymotide and related trisalicylide derivatives

JM Gnaim, BS Green, R Arad-Yellin…

Index: Gnaim, Jallal M.; Green, Bernard S.; Arad-Yellin, Rina; Keehn, Philip M. Journal of Organic Chemistry, 1991 , vol. 56, # 14 p. 4525 - 4529

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Citation Number: 9

Abstract

In order to improve the relatively low yield (a. 35%) previously observed in the synthesis of tri- o-thymotide (TOT, 1) from o-thymotic acid (21, the cyclodehydration was studied using a variety of conditions. The low yield is due to the formation of di-o-thymotide (DOT, 3), previously reported, and at least three other products (4 4 which apparently result from the acid-catalyzed decarboxylation of 2 and subsequent condensation with thymol (7). Using ...