e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Organic & biomolecular chemistry
Squalene–hopene cyclase: insight into the role of the methyl group on the squalene backbone upon the polycyclization cascade. Enzymatic cyclization products of …
To provide deep insight into the polycyclization reaction of squalene, some analogs were synthesized and incubated with the cell-free homogenates of the recombinant Escherichia coli encoding the wild-type squalene cyclase. The presence of C (6)–Me leads to an efficient polycyclization cascade. Substitution of the C (14)–H and the C (18)–H with a methyl group halted the polycylization reaction at the tricyclic ring stage having a 6/6/6-fused ring ...
