Tetrahedron

Synthesis of an adenine-pyridinaldoxime-acridine conjugate for recognition of abasic site lesions in DNA

M Chavarot, S Socquet, M Kotera, J Lhomme

Index: Chavarot, Murielle; Socquet, Stephane; Kotera, Mitsuharu; Lhomme, Jean Tetrahedron, 1997 , vol. 53, # 40 p. 13749 - 13756

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Citation Number: 9

Abstract

Based on the DNA abasic site targeted artificial enzyme (ATAc 1) previously developed in our laboratory, we designed and prepared a new molecule (2) incorporating a nucleophilic oxime function in the linker. A simple convergent strategy was used for the synthesis. The required pyridinic aldehyde derivative 9 was prepared by selenium oxide oxidation of the corresponding methylpyridine, and the two heteroaromatic moieties were successively ...