Reduction in glucose levels in STZ diabetic rats by 4-(2, 2-dimethyl-1-oxopropyl) benzoic acid: a prodrug approach for targeting the liver

…, DA Otero, WR Simpson, RJ Strohschein

Index: Bebernitz; Dain; Deems; Otero; Simpson; Strohschein Journal of Medicinal Chemistry, 2001 , vol. 44, # 4 p. 512 - 523

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Citation Number: 15

Abstract

The overproduction of glucose by the liver in NIDDM patients markedly contributes to their fasting hyperglycemia and is a direct consequence of the increased oxidation of excess free fatty acids (FFA) being released from the adipocyte. 2-(1, 1-Dimethylethyl)-2-(4- methylphenyl)[1, 3] dioxolane (SAH51-641, 1) has previously been demonstrated to reduce glucose levels in animal models of diabetes by reducing fatty acid oxidation and hence ...