Abstract A very easy access to new trifluoromethyl-hydroxyethylamine (Tf-HEA) derivatives by epoxide ring opening with amino-containing compounds, including aliphatic amines, aniline, aqueous ammonia, hydroxylamine, hydrazine, amino acids and a dipeptide, is described herein. The reactions were carried out in protic solvents, without the use of any catalyst or any other additive. A comparison of the efficiency of water, fluorinated and non- ...
