Tetrahedron Letters

Domino synthesis of 1, 3-diynes from 1, 1-dibromoalkenes: a Pd-catalyzed copper-free coupling method

MLN Rao, P Dasgupta, BS Ramakrishna, VN Murty

Index: Rao, Maddali L.N.; Dasgupta, Priyabrata; Ramakrishna, Boddu S.; Murty, Venneti N. Tetrahedron Letters, 2014 , vol. 55, # 25 p. 3529 - 3533

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Citation Number: 6

Abstract

Abstract Pd-catalyzed domino synthesis of 1, 3-diynes was accomplished using 1, 1- dibomoalkenes under copper-free coupling conditions. This domino procedure involves base mediated in situ generation of 1-bromoalkyne and its subsequent coupling to give 1, 3- diyne. The optimized copper-free coupling method afforded good to high yields of symmetrical 1, 3-diynes in a one-pot operation.