Only few years ago furoxan derivatives were found to play an important pharmacological role, as they are able to increase the cytosolic level of cGMP in human platelets, 1 to activate the rat liver soluble guanylate cyclase and to release NO when treated with thiol compounds under physiological conditions 2 resulting in a potent vasodilating effect. 3 Very recently it has also been discovered that furoxan derivatives exert anti-HIV1, antitrypanosomal and ...
