Synthesis of an optically active octahydro-2H-pyrido [1, 2-a] pyrazine based CNS agent

…, R Breitenbach, CW Murtiashaw, BC Vanderplas

Index: Urban, Frank J.; Breitenbach, Ralph; Murtiashaw, Charles W.; Vanderplas, Brian C. Tetrahedron: Asymmetry, 1995 , vol. 6, # 2 p. 321 - 324

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Citation Number: 9

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A synthesis of an optically active octahydro-2H-pyrido[1,2-a]pyrazine is presented. The key sequence involved the equilibration of an optically active cis-aldehyde to give the thermodynamic trans-aldehyde that was trapped by nitromethane anion. ... The equilibration of an ...