A thiazole derivative can be easily prepared, eg, from an α-thiocyanatoketone and a nitrogen nucleophile. In this work, α-bromopropiophenone was chosen as a starting compound. Since the carbonyl group facilitates nucleophilic substitution, bromine can be simply replaced with the thiocyanato group. The following reaction with hydroxylamine hydrochloride provides an intermediate, which undergoes a ring closure reaction. Finally, ...
