Tetrahedron Letters

Generation of rhodium enolates via retro-aldol reaction and its application to regioselective aldol reaction

K Murakami, H Ohmiya, H Yorimitsu, K Oshima

Index: Murakami, Kei; Ohmiya, Hirohisa; Yorimitsu, Hideki; Oshima, Koichiro Tetrahedron Letters, 2008 , vol. 49, # 15 p. 2388 - 2390

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Citation Number: 7

Abstract

The reaction of aldehydes or ketones with metal enolates is one of the most important reactions in organic synthesis. 1 Methods for the preparation of metal enolates have therefore been extensively studied, which include deprotonation of carbonyl compounds, reduction of α-halo carbonyl compounds, 2 and 1,4-addition of α,β-unsaturated carbonyl compounds. 3 Metal-catalyzed retro-aldol reaction of β-hydroxy carbonyl compounds is a potentially useful and ...