The human immunodeficiency virus type 1 (HIV-1) is the etiological agent of acquired immunodeficiency syndrome (AIDS). The viral reverse transcriptase (RT) of HIV-1 is one of the most promising targets for inhibition of HIV-1 replication; it can be inhibited by two classes of drugs that belong either to the nucleoside reverse transcriptase inhibitors (NRTIs) or to the nonnucleoside reverse transcriptase inhibitors (NNRTIs).[1–6] The HIV pandemic ...
