β-(S-Methyl) thioaspartic acid occurs as a posttranslational modification at position 88 in Escherichia coli ribosomal protein S12, a position that is a mutational hotspot resulting in both antibiotic-resistant and antibiotic-sensitive phenotypes. Critical to research designed to determine the biological function of β-(S-methyl) thioaspartic acid will be the availability of synthetic β-(S-methyl) thioaspartic acid as well as derivatives designed for peptide ...