Synthesis of new 2-acetyl and 2-benzoyl quinoxaline 1, 4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents

A Jaso, B Zarranz, I Aldana, A Monge

Index: Jaso, Andres; Zarranz, Belen; Aldana, Ignacio; Monge, Antonio European Journal of Medicinal Chemistry, 2003 , vol. 38, # 9 p. 791 - 800

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Citation Number: 113

Abstract

A series of 2-acetyl and 2-benzoyl-6 (7)-substituted quinoxaline 1, 4-di-N-oxide derivatives were synthesized and evaluated for in vitro antituberculosis activity. The results show that 2- acetyl-3-methylquinoxaline 1, 4-di-N-oxide derivatives with chlorine, methyl or methoxy group in position 7 of the benzene moiety (compounds 2, 4 and 6, respectively) and unsubstituted (3) have good antitubercular activity, exhibiting EC90/MIC values between ...