Synthesis, and biological evaluation of new 1, 3, 4-thiadiazolium-2-phenylamine derivatives against Leishmania amazonensis promastigotes and amastigotes

…, L Cysne-Finkelstein, LL Leon, A Echevarria

Index: Da Silva, Edson F.; Canto-Cavalheiro, Marilene M.; Braz, Viviane R.; Cysne-Finkelstein, Lea; Leon, Leonor L.; Echevarria, Aurea European Journal of Medicinal Chemistry, 2002 , vol. 37, # 12 p. 979 - 984

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Citation Number: 51

Abstract

1, 3, 4-Thiadiazolium-2-aminide, which is a class of mesoionic compounds, were tested against promastigote and amastigote forms of Leishmania amazonensis. Parasites were assayed with or without the drugs in axenic media, using pentamidine isethionate as a reference drug. The very promising results showed us the most active compounds were the 4′-and 3′-methoxy derivatives against promastigote forms, while the highest activity ...