ABSTRACT Six isomeric nitro-and methoxy anilines were condensed with vanillin to obtain Schiff's bases. A new series of 2-(4-hydroxy-3-methoxy phenyl)-1-thiazolidinone derivatives were synthesized by the cyclocondensation of Schiff's bases with mercapto acetic acid. The chemical structures of synthesized compounds were confirmed by elemental analysis, molecular weight determination, IR, 1H & 13C and DEPT-135 NMR spectral ...