Organic letters

Tandem intramolecular Nicholas and Pauson-Khand reactions for the synthesis of tricyclic oxygen-containing heterocycles

MM Quintal, KD Closser, KM Shea

Index: Quintal, Miriam M.; Closser, Kristina D.; Shea, Kevin M. Organic Letters, 2004 , vol. 6, # 26 p. 4949 - 4952

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Citation Number: 26

Abstract

Although both transformations incorporate dicobalt hexacarbonyl complexed alkynes, surprisingly little is known about sequential combinations of these two reactions. Several groups have studied intermolecular Nicholas reactions followed by intramolecular Pauson−Khand reactions to yield bicyclic products; 4 however, only Schreiber has investigated a transformation that involves both intramolecular Nicholas and Pauson−Khand reactions to furnish a tricyclic ring system. 5 ...