Mechanism-based inhibitors of prostaglandin. omega.-hydroxylase:(R)-and (S)-12-hydroxy-16-heptadecynoic acid and 2, 2-dimethyl-12-hydroxy-16-heptadecynoic …

…, BSS Masters, PR Ortiz de Montellano

Index: Burger, Alain; Clark, Joan E.; Nishimoto, Masazumi; Muerhoff, A. Scott; Masters, Bettie Sue Siler; Montellano, Paul R. Ortiz de Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1418 - 1424

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Citation Number: 11

Abstract

12-Hydroxy-16-heptadecynoic acid has been shown to selectively inactivate cytochrome P450 4A4, a pulmonary cytochrome P450 enzyme that catalyzes the w-hydroxylation of prostaglandins [Muerhoff, AS; Williams, DE; Reich, N. 0.; CaJacob, CA; Ortiz de Montellano, PR; Masters, BSS J. Biol. Chern. 1989, 264,749-7561. Potent, specific inhibitors of this enzyme are required to explore its physiological role. In a continuing effort to develop ...