Synthesis and anticancer activity of 2-alkylaminomethyl-5-diaryl-methylenecyclopentanone hydrochlorides and related compounds

J Wang, L Zhao, R Wang, M Lu, D Chen…

Index: Wang, Jingli; Zhao, Linxiang; Wang, Rui; Lu, Min; Chen, Duo; Jing, Yongkui Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1285 - 1291

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Citation Number: 10

Abstract

Eleven new diaryl-methylenecyclopentanone Mannich hydrochlorides and related compounds were synthesized with different modification on Mannich base and α, β- unsaturated bonds. The glutathione-binding ability, glutathione-s-transferase π (GSTπ) inhibition and antitumor effect of these compounds were compared. Compounds containing both Mannich base and α-unsaturated bond have GSH binding ability, GSTπ inhibitory ...