Synthesis and antiinflammatory activity of benzofuryloxyacetic acid derivatives

…, SA Zotova, TI Mukhanova, VM Lyubchanskaya…

Index: Grinev, A. N.; Zotova, S. A.; Mukhanova, T. I.; Lyubchanskaya, V. M.; Shvarts, G. Ya.; et al. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 3 p. 191 - 194 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 3 p. 291 - 294

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Abstract

5-(2-Phenylthiomethyl+ 3-carbethoxy-6-bromobenzofuryl) oxyacetic acid (IV) was prepared from the known 2-methyl-3-carbethoxy-5-hydroxy-6-bromobenzofuran [6]. Acylation of the last compound with acetic anhydride in the presence of triethylamine gave the 0-acetyl derivative (I). Bromination of I by N-bromosuccinimide (NBS) with illumination in the presence of benzoyl peroxide led to 2-bromoethyl-3-carbethoxy-5-acetoxy-6- ...