Synthesis and anti-inflammatory activity of celecoxib like compounds

…, S Yaseen, R Bashir, P Rathore, M Samim…

Index: Ovais, Syed; Yaseen, Shafiya; Bashir, Rafia; Rathore, Pooja; Samim, Mohammed; Singh, Surender; Nair, Vinod; Javed, Kalim Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 , vol. 28, # 5 p. 1105 - 1112

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Citation Number: 6

Abstract

Nine novel 4-[3-(4-Dimethylamino-phenyl)-5-aryl-4, 5-dihydro-pyrazol-1-yl]- benzenesulfonamides (2a-i) were synthesized and evaluated for their anti-inflammatory and antiproliferative activities. These compounds (2a-i) showed moderate to strong anti- inflammatory activity in carrageenan rat paw oedema test. Compounds 2b, 2d and 2g showing comparable anti-inflammatory activity to that of reference drug celecoxib were ...