Synthesis of Tetrahydronaphthalene Lignan Esters by Intramolecular Cyclization of Ethyl p-Azidophenyl-2-phenylalkanoates and Evaluation of the Growth Inhibition of …

…, F Piedade, MJ Calhorda, R Abramovitch…

Index: Abramovitch, Rudolph A.; Cooper, Melanie; Iyer, Suresh; Jeyaraman, Ramasubbu; Rodriguez, J. Augusto Rosario Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4819 - 4820

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Citation Number: 5

Abstract

Intramolecular cyclization via nitrenium ion of 2-phenylpentanoic/2-phenylbutanoic acid esters with a terminal p-azidophenyl group gives direct access to tetrahydronaphthalene lignan esters. The p-azidophenyl-substituted butanoate led to an ethyl spirodienone