There are numerous significant and important reactions in organic synthesis which require the addition of hexamethylphosphoric triamide (HMPA) to render them viable. 1 HMPA is a dipolar aprotic compound with a superb ability to form cation–ligand complexes and it can enhance the rates of a wide variety of main group organometallic reactions. In addition, it can also influence the regio-and stereo-chemistry of key reactions such as enolate ...
