A Convenient Synthesis of 2-Alkylcyclopentenones, Important Prostaglandin Intermediates

T Wakamatsu, K Hashimoto…

Index: Wakamatsu,T. et al. Synthetic Communications, 1978 , vol. 8, p. 319 - 326

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Citation Number: 12

Abstract

Abstract 2-Alkylcyclopentenones,(1) and (2), are in general useful precursors in the synthesis of the prostaglandins assembly via conjugate addition of organometallic derivatives. 1 For example, the cyclopentenone (1) has served as a versatile prostaglandin intermediate for a variety of 11-deoxyprostanoids such as PGB1, 11-deoxy-PGE1, 11, 15-bis- deoxy-PGE1, 11-deoxy-13, 14-dihydro-PGE1, 11-deoxy-13, 14-dihydro-PGF1α, and 11- ...