A Single Phosphine Ligand Allows Palladium??Catalyzed Intermolecular C O Bond Formation with Secondary and Primary Alcohols

X Wu, BP Fors, SL Buchwald

Index: Wu, Xiaoxing; Fors, Brett P.; Buchwald, Stephen L. Angewandte Chemie - International Edition, 2011 , vol. 50, # 42 p. 9943 - 9947

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Citation Number: 85

Abstract

Aryl alkyl ethers are present in many naturally occurring and medicinally relevant compounds.[1] Copper [2]-and palladiumcatalyzed CÀO bond-forming reactions have become effective strategies for their preparation. Although reasonably efficient palladium catalysts for the coupling reactions of phenols [3] and tertiary alcohols,[4] which lack β- hydrogen atoms, have been developed, much less progress in the realization of a ...