. GAMMA.-Pyrones from Gonystylus keithii, as New Inhibitors of Parathyroid Hormone (PTH)-Induced Ca Release from Neonatal Mouse Calvaria.

T Kanazawa, Y Ohkawa, T Kuda, Y MINOBE…

Index: Kanazawa, Tsutomu; Ohkawa, Yuki; Kuda, Takashi; Minobe, Yasushi; Tani, Tadato; Nishizawa, Makoto Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 6 p. 1046 - 1051

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Citation Number: 9

Abstract

New γ-pyrones, 9'-oxopodopyrone (3) and 8-methyl-9'-oxopodopyrone (4) were isolated from the leaves of Gonystylus keithii, along with known γ-pyrones, 10'-oxopodopyrone (1) and 8-methyl-10'-oxopodopyrone (2). These γ-pyrones markedly inhibited the bovine parathyroid hormone (PTH)-induced Ca release from neonatal mouse calvaria in vitro. It is the first time that γ-pyrones showed inhibitory effects on bone resorption, and these ...