Sequential One??Pot Addition of Excess Aryl??Grignard Reagents and Electrophiles to O??Alkyl Thioformates

…, K Morikawa, T Maruyama

Index: Murai, Toshiaki; Morikawa, Kenta; Maruyama, Toshifumi Chemistry - A European Journal, 2013 , vol. 19, # 39 p. 13112 - 13119

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Citation Number: 7

Abstract

Abstract The sequential addition of aromatic Grignard reagents to O-alkyl thioformates proceeded to completion within 30 s to give aryl benzylic sulfanes in good yields. This reaction may begin with the nucleophilic attack of the Grignard reagent onto the carbon atom of the O-alkyl thioformates, followed by the elimination of ROMgBr to generate aromatic thioaldehydes, which then react with a second molecule of the Grignard reagent at the ...