In order to investigate the effect of the fixation of the orientations of the two long chains, three types of novel derivatives of scavenger receptor inhibitor 1 were synthesized, and their biological activities were evaluated. Among the novel derivatives, 2, 4-bis (octadecanoylamino) benzenesulfonic acid sodium salt (4d) showed the most potent inhibitory activity against the incorporation of 1, 1′-dioctadecyl-3, 3, 3′, 3′- ...