Class III antiarrhythmic activity of novel substituted 4-[(methylsulfonyl) amino] benzamides and sulfonamides

JW Ellingboe, W Spinelli, MW Winkley…

Index: Ellingboe, John W.; Spinelli, Walter; Winkley, Michael W.; Nguyen, Thomas T.; Parsons, Roderick W.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 705 - 716

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Citation Number: 83

Abstract

The synthesis and Claw Ill antiarrhythmic activity of a seriea of 4 [(methylsulfonyl) amino] be&des and sulfonamides are described. Selected compounds show a potent Class I11 activity and are devoid of effects on conduction both in vitro (dog Purkinje fibers) and in vivo (anesthetized dogs). Compounds having a 2-aminobenzimidazole group were found to be the most potent, and one compound having this heterocycle (5, WAY-123,398) was ...