Palladium-catalyzed oxidative arylhalogenation of alkenes: Synthetic scope and mechanistic insights

D Kalyani, AD Satterfield…

Index: Kalyani, Dipannita; Satterfield, Andrew D.; Sanford, Melanie S. Journal of the American Chemical Society, 2010 , vol. 132, # 24 p. 8419 - 8427

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Citation Number: 57

Abstract

This article describes the development of a Pd-catalyzed reaction for the arylhalogenation (halogen= Cl or Br) of diverse α-olefins by oxidatively intercepting Mizoroki− Heck intermediates. These transformations afford synthetically useful 1, 2-and 1, 1- arylhalogenated products in good yields with good to excellent selectivities that can be modulated by changing the nature of the halogenating reagent and/or the reaction ...