e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Molecules
Synthesis, DNA binding and topoisomerase I inhibition activity of thiazacridine and imidazacridine derivatives
…, T Gonçalves da Silva, R Olímpio de Moura…
Index: Lafayette, Elizabeth Almeida; De Almeida, Sinara Monica Vitalino; Da Rocha Pitta, Marina Galdino; Beltrao, Eduardo Isidoro Carneiro; Da Silva, Teresinha Goncalves; De Moura, Ricardo Olimpio; Da Rocha Pitta, Ivan; De Carvalho Junior, Luiz Bezerra; De Lima, Maria Do Carmo Alves Molecules, 2013 , vol. 18, # 12 p. 15035 - 15050
Abstract: Thiazacridine and imidazacridine derivatives have shown promising results as tumors suppressors in some cancer cell lines. For a better understanding of the mechanism of action of these compounds, binding studies of 5-acridin-9-ylmethylidene-3-amino-2-thioxo- thiazolidin-4-one, 5-acridin-9-ylmethylidene-2-thioxo-thiazolidin-4-one, 5-acridin-9- ylmethylidene-2-thioxo-imidazolidin-4-one and 3-acridin-9-ylmethyl-thiazolidin-2, 4-dione ...
