Synthetic Studies on Condensed-Azole Derivatives. V. Synthesis and Anti-asthmatic Activities of. OMEGA.-Sulfamoylalkyloxy (1, 2, 4) triazolo (1, 5-b) pyridazines.

M Kuwahara, Y Kawano, M Kajino, Y ASHIDA…

Index: Kuwahara, Masaaki; Kawano, Yasuhiko; Kajino, Masahiro; Ashida, Yasuko; Miyake, Akio Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 9 p. 1447 - 1457

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Citation Number: 9

Abstract

A series of novel ([1, 2, 4] triazolo [1, 5-b] pyridazin-6-yl) oxyalkylsulfonamides was synthesized and evaluated for the ability to inhibit platelet activating factor (PAF)-induced bronchoconstriction in guinea pigs. The compounds bearing a gem-dialkyl or a cycloalkylidene group at the 2 position of the sulfamoylpropyloxy group in the side chain and a methyl group at the 7 position were found to have potent activity. Among them, 2, 2- ...