Studies on pyrazines. Part 34. 1 Synthetic approach, stability and tautomerism of 2, 6-dihydroxypyrazines

…, K Matsumoto, M Takishima, K Mochizuki

Index: Sato, Nobuhiro; Matsumoto, Kaori; Takishima, Masayuki; Mochizuki, Katsura Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 21 p. 3167 - 3172

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Citation Number: 4

Abstract

Demethylation of 2, 6-dimethoxy-3, 5-diphenylpyrazine with iodotrimethylsilane gives the corresponding 2, 6-dihydroxy-and 2-hydroxy-6-methoxy-pyrazines, whilst the 3-methyl-5- phenyl analogue affords only monohydroxy compounds. In contrast, 2, 6-dimethoxy-3, 5- dimethylpyrazine decomposes completely under the demethylation conditions. Hydrolysis of 2, 6-diacetoxypyrazines succeeds only in the formation of 2, 6-dihydroxy-3, 5- ...