Experiments in the 5H??dibenzo [a, d] cycloheptene series II. Synthesis of some esters and piperazine derivatives of 5H??dibenzo [a, d] cycloheptene

C Van der Stelt, A Haasjes…

Index: van der Stelt,C. et al. Recueil des Travaux Chimiques des Pays-Bas, 1965 , vol. 84, p. 1466 - 1477

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Citation Number: 12

Abstract

Abstract The synthesis of a number of acids in the 5H-dibenzo [a, d] cycloheptene series is described including the 5-carboxylic acid and its 10, 11-dihydro analogue, 5H-dibenzo [a, d] cycloheptene-5-acetic acid and its 10, 11-dihydro derivative. The latter acid was prepared by several routes. Treatment of its acid chloride with stannic chloride yielded 2, 6, 7, 1 1b- tetrahydro-1H-dibenzo [c, d, h] azulen-2-one, which by reductive amination with ...

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[Tucker, Thomas J.; Lumma, William C.; Dale Lewis; Gardell, Stephen J.; Lucas, Bobby J.; Sisko, Jack T.; Lynch, Joseph J.; Lyle, Elizabeth A.; Baskin, Elizabeth P.; Woltmann, Richard F.; Appleby, Sandra D.; Chen, I.-Wu; Dancheck, Kimberley B.; Naylor-Olsen, Adel M.; Krueger, Julie A.; Cooper, Carolyn M.; Vacca, Joseph P. Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3687 - 3693]

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