(Phenylpiperidinyl) cyclohexylsulfonamides: Development of α 1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower …

…, S Li, PJ Connolly, V Pulito, J Liu, SA Middleton

Index: Chiu, George; Li, Shengjian; Connolly, Peter J.; Pulito, Virginia; Liu, Jingchun; Middleton, Steven A. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 3930 - 3934

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Citation Number: 3

Abstract

Although α1 adrenergic receptor blockers can be very effective for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS), their usage is limited by CV- related side-effects that are caused by the subtype non-selective nature of the current drugs. To overcome this problem, it was hypothesized that a α1a/1d subtype selective antagonist would bring more benefit for the therapy of BPH/LUTS. In developing such selective α1a/ ...