Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2, 2′: 6′, 2 ″-, 2, 2′: 6′, 3 ″-and 2, 2′: 6′, 4 ″-Terpyridine derivatives

…, H Choi, CS Lee, JA Kim, TC Jeong, C Chang…

Index: Zhao, Long-Xuan; Kim, Tae Sung; Ahn, Soo-Hyun; Kim, Tae-Hyung; Kim, Eun-kyung; Cho, Won-Jea; Choi, Heesung; Lee, Chong-Soon; Kim, Jung-Ae; Jeong, Tae Cheon; Chang, Ching-jer; Lee, Eung-Seok Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 19 p. 2659 - 2662

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Citation Number: 83

Abstract

For the development of new anticancer agents, 2, 2′: 6′, 2 ″-, 2, 2′: 6′, 3 ″-and 2, 2′: 6′, 4 ″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure–activity relationship studies indicated that 2, 2′: 6′, 2 ″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2, 2′: 6′, 3 ″-and 2, 2′: 6′, 4 ″-terpyridine derivatives ...