An efficient synthesis of the three halogenated naturally occurring products, pterulone (2), pterulone B (3) and alcohol 5, and of a wide range of related unnatural analogues has been achieved starting from the two readily available 1-benzoxepine sulfonyl-containing intermediates 6a and 6b. The biological activities of pterulone and some of the synthesized analogues were tested against a wide spectrum of phytopathogenic fungi.
![1-[3-(chloromethylidene)-1-benzoxepin-7-yl]ethanone Structure](https://image.chemsrc.com/caspic/359/369376-61-4.png)
