2, 3-Diarylindenes and 2, 3-diarylindenones: synthesis, molecular structure, photochemistry, estrogen receptor binding affinity, and comparisons with related …

GM Anstead, RJ Altenbach, SR Wilson…

Index: Anstead; Altenbach; Wilson; Katzenellenbogen Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1316 - 1326

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Citation Number: 47

Abstract

Two 2, 3-diphenylindene and-indenone systems, with potential fluorescent and photofluorogenic properties, were prepared and studied as ligands for the estrogen receptor. The indene systems were prepared by Friedel-Crafts cyclization of appropriate a- benzyl desoxybenzoin systems, and the indenones either by oxidation of the indenes, by cyclization of a-benzoyl desoxybenzoins, or by acylium ion attack on tolan. ...