Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and …

V Crécy-Lagard, G Phillips, LL Grochowski…

Index: De Crecy-Lagard, Valerie; Phillips, Gabriela; Grochowski, Laura L.; Yacoubi, Basma El; Jenney, Francis; Adams, Michael W. W.; Murzin, Alexey G.; White, Robert H. ACS Chemical Biology, 2012 , vol. 7, # 11 p. 1807 - 1816

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Citation Number: 14

Abstract

C-1 carriers are essential cofactors in all domains of life, and in Archaea, these can be derivatives of tetrahydromethanopterin (H4-MPT) or tetrahydrofolate (H4-folate). Their synthesis requires 6-hydroxymethyl-7, 8-dihydropterin diphosphate (6-HMDP) as the precursor, but the nature of pathways that lead to its formation were unknown until the recent discovery of the GTP cyclohydrolase IB/MptA family that catalyzes the first step, the ...