Dynamic double kinetic resolution of amines and alcohols under the cocatalysis of Raney Nickel/Candida antarctica Lipase B: from concept to application

B Xia, G Cheng, X Lin, Q Wu

Index: Xia, Bo; Cheng, Guilin; Lin, Xianfu; Wu, Qi European Journal of Organic Chemistry, 2014 , vol. 2014, # 14 p. 2917 - 2923

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Citation Number: 5

Abstract

Abstract Herein, we have established a dynamic double kinetic resolution (DDKR) strategy under the co-catalysis of Raney nickel and Candida antarctica lipase B (CAL-B) for the one- pot simultaneous resolution of primary amines and secondary alcohols (or esters). The DDKR strategy was successfully applied to the resolution of a series of racemic amines and secondary alcohols (or esters) as well as mexiletine, an important antiarrhythmic agent. ...