Synthetic Studies on Anthracyclinones. VI. The Friedel-Crafts Condensation between 3-Methoxyphthalic Anhydride and α-Naphthol Derivatives

Z HORII, H HAKUSUI, T MOMOSE…

Index: Horii,Z.I. et al. Chemical and Pharmaceutical Bulletin, 1968 , vol. 16, p. 1251 - 1261

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Citation Number: 6

Abstract

The Friedel-Crafts condensation of 3-methoxyphthalic anhydride (IV) gave predominantly 3- methoxy-2-aroylbenzoic acid types. On employment of anhydrous aluminum chloride as a condensing agent, this tendency was exclusive. The Grignard reaction of IV also gave a similar result. The boron trioxide catalyzed condensation of 3-hydroxyphthalic anhydride (IVa), on the contrary, gave exclusively 2-hydroxy-6-aroylbenzoic acid types. The ...