Synthesis and DNA strand breakage activity of some 1, 4-diazepines.

…, Y Iwase, Y Goto, F Miake, T Yamaguchi, S Ito…

Index: Mibu, Nobuko; Yukawa, Miho; Kashige, Nobuhiro; Iwase, Yukiko; Goto, Yoshinobu; Miake, Fumio; Yamaguchi, Tadatoshi; Ito, Shigeru; Sumoto, Kunihiro Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 1 p. 27 - 31

Full Text: HTML

Citation Number: 10

Abstract

Reactions of 1, 3-propanediamine with α-dicarbonyl compounds (1a—e) were examined and various condensed heterocyclic compounds such as 1, 4-diazepines (2) and 3- pyrimidine derivatives (3) were obtained. Some of 1, 4-diazepines (2) showed DNA strand breakage activity.